ea0013p186 | Diabetes, metabolism and cardiovascular | SFEBES2007
McGee Kirsty C
, Hardo Faddy J
, Baker Adam R
, Tripathi Gyanendra
, Creely Steven J
, da Silva Nancy F
, Kumar Sudhesh
, Clapham John C
, McTernan Philip G
Mitochondrial dysfunction has been implicated in the pathogenesis of obesity and Type 2 Diabetes Mellitus (T2DM). Recent research has investigated the role of mitochondria in skeletal muscle and suggesting mitochondrial dysregulation may be linked to T2DM. To date few studies have focused on the role of human adipose tissue (AT) in energy homoeostasis. Therefore we investigated a number of mitochondrial genes including PPARγ co-activator1 (PGC1α, mitochondrial biogen...